Multiple Allergies Diagnosis and Treatment

Expert care for complex allergic conditions affecting respiratory, skin and digestive systems

Our specialist team provides comprehensive assessment and treatment for patients with multiple allergies. Led by Professor Gideon Lack, we combine groundbreaking research with personalised care plans to help you manage complex symptoms and improve quality of life.

Precise identification of all allergic triggers affecting different body systems
Coordinated treatment approach addressing each allergic condition simultaneously
Practical strategies to manage complex allergies in everyday life
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What are multiple allergies?

Multiple allergies occur when a person reacts to more than one allergen, experiencing different allergic conditions simultaneously or sequentially. This can include combinations of food allergies, environmental allergies, and allergic diseases such as asthma, eczema, and allergic rhinitis.

This increasingly common condition affects up to 30% of children with allergies and requires specialised management. Multiple allergies often create complex challenges that go beyond treating each condition in isolation, as symptoms can overlap and interact.

How multiple allergies develop

Multiple allergies typically follow a pattern known as the "allergic march" or "atopic march":
  • The immune system becomes sensitised to various allergens through different exposure routes
  • Inflammation and barrier dysfunction in one system (like the skin) can increase susceptibility to allergies in other systems
  • Genetic factors predispose some individuals to develop multiple allergic conditions
  • Environmental exposures influence which specific allergies develop
This progression often begins with eczema in infancy, followed by food allergies in early childhood, and later developing into asthma and allergic rhinitis. Professor Lack's research has been instrumental in understanding these connections and developing preventive strategies.

Common symptoms

Multiple allergies often present with overlapping and compounding symptoms that can be challenging to attribute to specific triggers:
Complex symptom patterns
  • Simultaneous reactions affecting multiple body systems
  • Cascading symptoms where one allergic response triggers others
  • Variable symptom intensity depending on combined allergen exposure
  • Persistent symptoms that never fully resolve due to ongoing exposure to different allergens
Mixed allergic presentations
  • Eczema flares triggered by both food and environmental allergens
  • Combined upper and lower respiratory symptoms (rhinitis plus asthma)
  • Skin reactions that worsen during seasonal pollen exposure
  • Digestive symptoms coinciding with respiratory or skin flares
Prolonged or treatment-resistant reactions
  • Extended recovery periods after exposure
  • Incomplete response to treatments that would normally control single allergies
  • Symptoms that persist despite avoiding one known allergen
  • More frequent "breakthrough" symptoms despite standard prevention measures
Heightened reactivity states
  • Decreased threshold for reactions when multiple systems are activated
  • Reactions to trace amounts of allergens that wouldn't normally cause symptoms
  • More severe allergic responses during peak exposure periods
  • Increased susceptibility to developing new sensitivities

Common triggers

Patients with multiple allergies typically show recognisable patterns of allergic sensitivities rather than random combinations:
Atopic clustering
  • The "allergic triad": eczema, asthma, and allergic rhinitis occurring together
  • Food allergy clusters: patients allergic to one nut often react to multiple nuts
  • Dairy and egg allergies frequently co-occurring with wheat sensitivity
  • Multiple seasonal pollen allergies (tree, grass, and weed) in the same patient
Cross-reactivity syndromes
  • Oral allergy syndrome: reactions to fresh fruits and vegetables in patients with pollen allergies
  • Latex-fruit syndrome: allergies to latex accompanied by reactions to banana, avocado, and kiwi
  • Dust mite and shellfish cross-reactivity due to shared tropomyosin proteins
  • Pollen-food syndromes specific to regional allergen profiles
Environmental and food combinations
  • House dust mite sensitivity linked with increased seafood allergy risk
  • Pet allergies frequently accompanying multiple pollen sensitivities
  • Mould allergies co-occurring with certain food intolerances
  • Skin contact allergens often developing alongside respiratory allergies
Sensitisation cascades
  • Initial allergies creating vulnerability to secondary sensitivities
  • Progressive development of new allergies following a predictable timeline
  • Foods commonly triggering multiple chemical sensitivities
  • Environmental allergen exposure increasing risk for food allergy development

Impact on daily life

Multiple allergies affect people of all ages and can significantly interfere with many aspects of daily life.
For children
  • Complex dietary restrictions affecting school lunches, parties, and social events
  • Managing multiple medications and treatment routines
  • Disrupted sleep from various symptoms (itching, breathing issues)
  • Challenges in explaining different allergic needs to teachers and caregivers
  • Frequent medical appointments interfering with school attendance
  • Reduced participation in certain activities due to combined triggers
For adults
  • Increased time managing multiple treatment regimens
  • Difficulty identifying specific triggers when symptoms overlap
  • Workplace challenges when managing environmental and food allergies
  • Heightened anxiety due to unpredictable symptom patterns
  • Complex food avoidance affecting social dining and travel
  • The emotional burden of managing multiple chronic conditions

When to seek specialist care

Consider specialist care for multiple allergies if:
Symptoms affect multiple body systems (skin, respiratory, digestive)
You notice signs of the allergic march in your child
It's difficult to identify specific triggers for your symptoms
Standard treatments aren't effectively controlling your conditions
Cross-reactivity between allergens is suspected
You need expert guidance on managing multiple medications
Allergies significantly impact quality of life or daily activitie
Severe allergic reactions to food
Early specialist assessment particularly benefits children, potentially modifying the progression of allergic disease.
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How we can help

Our approach to multiple allergies combines comprehensive assessment with personalised treatment plans designed to address each allergic condition while recognising how they interact.
Comprehensive assessment
Our specialists take a systematic approach to untangle complex allergic conditions:
Detailed allergy history mapping the timeline of symptom development
Strategic testing for both food and environmental triggers simultaneously
Advanced diagnostics to identify cross-reactivity patterns
Coordinated assessment of multiple body systems affected by allergies
Evaluation of how different allergic conditions influence each other
Effective treatments
We provide treatments addressing each allergic condition:
Personalised medication plans tailored to your specific allergic profile
Allergen-specific immunotherapy for environmental allergies
Targeted biological treatments for severe allergic conditions
Advanced eczema management protocols
Early intervention strategies to potentially alter the allergic march
Careful monitoring of all allergic conditions to adjust treatment as needed
Practical management strategies
Our patient-centred approach focuses on practical strategies for daily life:
Clear food avoidance guidance with nutritional support
Environmental modification recommendations
Comprehensive emergency action plans
Practical approaches to managing allergies in schools or workplaces
Digital tools to help track symptoms and identify patterns
Support for families managing complex allergic conditions

Why choose LACK Clinic for multiple allergy care

Led by Professor Gideon Lack, we bring world-leading expertise to the treatment of complex allergic conditions:
Pioneering research that has reshaped understanding of allergic disease
Unique expertise in the connections between different allergic conditions
Integrated approach treating the whole patient, not just individual symptoms
Team of specialists skilled in managing complex allergic profiles
Focus on minimising disruption to daily life despite multiple allergies
Access to the latest diagnostic and treatment approaches
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Eczema
“As far as our family is concerned, Professor Lack is a miracle worker. We trust his advice implicitly and are very lucky to have him as our daughter’s specialist.”
Eczema
28th Sept 2024
Eczema
verified patient

Pioneering research, personalised care

Our approach is informed by Professor Lack's landmark studies that have transformed allergy prevention and treatment globally. We apply these scientific discoveries through personalised care plans that address the unique challenges of multiple allergies, helping patients manage complex conditions more effectively and with less disruption to daily life.
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Your questions answered

What is the "allergic march" and can it be prevented?

The allergic march describes the typical progression of allergic conditions, often starting with eczema in infancy, followed by food allergies, and later developing into asthma and allergic rhinitis. This pattern occurs because early skin barrier dysfunction can lead to allergic sensitisation through the skin.

Research, including Professor Lack's studies, suggests the march can potentially be modified through:

  • Early, proactive management of eczema to maintain skin barrier function
  • Appropriate introduction of allergens through the digestive system
  • Timely treatment of each allergic condition as it develops
  • Regular assessment and monitoring of children with early allergic signs

Our specialists can develop personalised strategies to potentially reduce the risk of additional allergies developing, particularly in young children showing early signs of allergic tendencies.

How do you diagnose which specific allergies someone has when symptoms overlap?

Diagnosing multiple allergies with overlapping symptoms requires detective work. Our process involves:

  • Digital symptom diaries to identify revealing patterns and correlations
  • Strategic testing that prioritizes the most likely triggers based on history
  • Specialised protocols for distinguishing between similar allergic reactions
  • Sequential testing to understand how different allergic conditions interact
  • Challenge testing under controlled conditions to confirm ambiguous results

This systematic approach helps us untangle complex cases where traditional diagnostics might miss important connections or attribute symptoms to the wrong triggers.

Can having one allergy make you more likely to develop others?

Yes, having one allergic condition significantly increases the likelihood of developing others. This phenomenon, sometimes called "allergic clustering," occurs because:

  • The underlying immune dysregulation tends to affect multiple systems
  • One allergy can physically alter tissues, creating pathways for new sensitivities
  • The body's threshold for allergic reactions generally lowers
  • Environmental factors that triggered one allergy often contribute to others

Professor Lack's research has been particularly influential in understanding how early allergic conditions can cascade into multiple allergies, which guides our preventive approach and early intervention strategies.

How do you manage treatment when someone has multiple allergies?

Managing multiple allergies requires a strategic approach unlike treating single allergies. Our treatment philosophy focuses on:

  • Understanding the "driver allergies" that trigger or worsen other conditions
  • Developing tiered treatment plans that address interrelated symptoms together
  • Using multifunctional medications that target shared inflammatory pathways
  • Creating unified action plans instead of separate plans for each condition
  • Balancing treatment intensity with practical considerations for daily life
  • Adopting preventive approaches for conditions that haven't yet manifested

The goal is a coherent treatment strategy rather than a collection of separate approaches that might conflict or create unnecessary complexity.

Can children outgrow multiple allergies?

Many children do outgrow certain allergies, even when they have multiple allergic conditions. The likelihood varies depending on:

  • The specific allergies involved (milk and egg allergies are more commonly outgrown than peanut or tree nut allergies)
  • The severity of initial reactions
  • Specific IgE levels over time
  • The presence of other allergic conditions

Regular reassessment allows us to track changes in allergic sensitivity and potentially reintroduce foods that have been outgrown. Even when complete resolution doesn't occur, many children experience decreased sensitivity as they grow, potentially allowing more flexibility in management approaches.

Ready to take control of your multiple allergies?

Our specialist team can help you navigate the challenges of managing multiple allergic conditions with a comprehensive, coordinated approach tailored to your specific needs.
Speak to our Team